ArticleCureus2025
BRCA1 and BRCA2 Gene Mutations in Reproductive-Aged Women With Polycystic Ovarian Syndrome.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- BRCA1 alleviates inflammation, oxidative stress, and ovarian granulosa cell apoptosis by inhibiting endoplasmic reticulum stress, thereby ameliorating polycystic ovary syndrome.European journal of medical research · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPolycystic ovarian syndrome (PCOS) is a heterogeneous condition influenced by genetic, environmental, and lifestyle factors. The aim of this study was to evaluate the relationship between BRCA1 and BRCA2 gene mutations with PCOS and to determine the sociodemographic and clinical risk factors. AIM AND
objectiveThis study seeks to analyze mutations in the BRCA1 and BRCA2 genes among women with PCOS in the Vijayapura region. METHODOLOGY: In total, there were 96 individuals included (49 PCOS individuals and 47 healthy controls). Blood samples were collected for genetic analysis, and the anthropometry parameters, menstrual irregularities, and ultrasound findings were recorded. Genomic DNA was extracted to undergo polymerase chain reaction (PCR) followed by automated sequencing. Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 20.0 (Released 2011; IBM Corp., Armonk, New York, United States), with a significance level set at p<0.05.
resultsOutcomes presented an association between rural residency, educational status, and consanguineous marriage, as well as homemaker and PCOS (p=0.001 for all). Abnormal menstruation and dysmenorrhea (p=0.001) occurred frequently (69.4%) in women with PCOS (89.8% had acne). BRCA1 mutations exhibited a significant association with PCOS (p=0.045), where 8.2% of cases expressed the rs1555600862 (C>G variant, a likely benign missense mutation). Conclusion: PCOS women often have a hormonal imbalance and ovarian dysfunction. Detecting BRCA gene mutations in women with PCOS is very crucial because these mutations are linked to higher risks of breast and ovarian cancers. Early detection of the BRCA gene mutation status can provide clear, valuable insight in terms of the prevention of complications and treatment options.
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