ReviewCureus2025
Restless Legs and Iron Deficiency: Unraveling the Hidden Link and Unlocking Relief.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Sympathetic Activation and Sleep-Related Movements: Integrating Autonomic, Dopaminergic, and Iron Deficiency Mechanisms.Brain sciences · 2026Review
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.Food science & nutrition · 2025Article
- Risk factors and mediating mechanisms of restless legs syndrome in patients undergoing maintenance hemodialysis: a longitudinal cohort study combined with Mendelian randomization analysis.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS), also called Willis-Ekbom disease (WED), is a condition marked by an overwhelming urge to move the legs, particularly during rest or at night. Treatments, including intravenous iron, show potential, but further studies are needed to establish their long-term safety and efficacy. The findings integrate various studies to better understand diagnosis, mechanisms, and treatment options for RLS. This review explores the connection between RLS and iron deficiency, emphasizing iron metabolism and its potential role in disease development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.