ReviewCureus2025
Gene-Confirmed Primary Aneurysmal Bone Cysts of the Jaws: A Qualitative Systematic Review of Clinical, Radiologic, and Histopathological Features.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aneurysmal bone cyst (ABC) is rarely a clinical diagnosis on first take; hence, data pertaining to primary ABC assists in differentiating lesions from related pathologies. The cases of primary ABCs were managed by curettage even with extensive cortical plate expansion, whereas secondary ABCs were managed according to primary pathology. The present review retrospectively studies the case reports of primary ABCs affecting the jaws, reported from the year 2000 (the time when USP6 to CDH 11 gene translocation was detected) to date, to identify cases that were diagnostically confirmed with gene analysis. Confirmed primary ABCs of jaws as defined by the World Health Organization (WHO) 2020 classification were included after a thorough literature search. In cases where gene analysis was not done, criteria considered to diagnose as primary ABC (clinical-radiological characteristics and histopathological features) were studied. Recurrence rate and prognosis were analyzed. A male predominance was noted with a ratio of 2:1. The age group between 10 and 20 years and the mandibular posterior region, followed by the temporomandibular joint (TMJ), were mainly affected. Around 22 of 33 cases showed both buccal and lingual cortical plate expansion. Blown-out cortices, fluid levels on magnetic resonance imaging (MRI) or contrast computed tomography (CT), altered blood, and the key histopathological feature of large blood-filled spaces surrounded by fibrovascular septa were the main clues for diagnosis. Around 28 of 33 cases showed giant cells, and 14 of 33 cases showed calcifications/ossifications. Recurrence was noted in 6 of 13 cases treated by curettage. A majority of primary ABCs are believed to exhibit gene mutations; however, genetic analysis was infrequently performed in the reviewed cases. Since the gene analysis may not be feasible in all cases, studies on histopathological analysis and immunohistochemical (IHC) markers to find clues for confirmatory diagnosis are in need.
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