ArticleFrontiers in medicine2025
Myocardial impairment in rheumatoid arthritis patients with normal left ventricular function: findings from speckle tracking echocardiography.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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11 authors.
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Abstract
Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition recognized for elevating cardiovascular morbidity and mortality, even in the absence of overt cardiovascular symptoms. Traditional echocardiogram frequently overlooks early myocardial failure, necessitating more sensitive imaging modalities, such as speckle tracking echocardiography (STE), to effectively diagnose subclinical left ventricular systolic dysfunction (LVSD). Timely identification of cardiac involvement is essential for reducing long-term cardiovascular risks in people with rheumatoid arthritis. Objectives: This study sought to (i) determine if STE can identify subclinical myocardial dysfunction in RA Patients with normal left ventricular function as assessed by transthoracic echocardiography and (ii) identify clinical and biological factors linked to this extra-articular manifestation. Methods: A total of 36 RA patients and 36 matching healthy controls were included. All subjects underwent standard transthoracic echocardiogram and speckle tracking STE to evaluate left ventricular function. Global longitudinal strain (GLS) was employed to identify subclinical left ventricular systolic dysfunction, with a GLS threshold of ≤ - 18% signifying LVSD. Clinical and biochemical variables, such as hemoglobin concentrations, diabetes mellitus, and disease activity (DAS28-CRP), were evaluated to determine their correlation with compromised myocardial strain. Results: RA patients had a significantly diminished GLS compared to healthy controls (18.99 ± 2.81% vs. 20.42 ± 1.33%, Conclusion: STE identified subclinical LVSD in a significant number of RA patients with normal LVEF, emphasizing its effectiveness in early cardiovascular risk assessment. Hemoglobin levels were a crucial predictor of subclinical LVSD, highlighting the necessity of thorough cardiovascular risk evaluations in RA, especially for individuals with anemia or other concomitant conditions. Incorporating STE into standard assessments may facilitate early interventions and enhance long-term cardiovascular outcomes for patients with RA.
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