Evidence map›Paper›PMID 40385547›Full record

ArticleBioengineering & translational medicine2025

Amelioration of biased neuronal differentiation in humanized mouse model of valproic acid-induced autism by precisely targeted transcranial magnetic stimulation.

Yilin Hou, Youyi Zhao, Dingding Yang, Tingwei Feng, Yuqian Li, Xiang Li, Zhou'an Liu, Xiao Yan, Hui Zhang, Shengxi Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering & translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yilin HouDepartment of Military Medical Psychology Air Force Medical University Xi'an Shaanxi P. R. China.
Youyi ZhaoState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research, Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology Air Force Medical University Xi'an Shaanxi P. R. China.
Dingding YangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine Air Force Medical University Xi'an Shaanxi P. R. China.
Tingwei FengDepartment of Military Medical Psychology Air Force Medical University Xi'an Shaanxi P. R. China.
Yuqian LiDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine Air Force Medical University Xi'an Shaanxi P. R. China.
Xiang LiKey Laboratory of Biomedical Information and Engineering, School of Life Sciences and Technology, Ministry of Education Xi'an Jiaotong University Xi'an Shaanxi P. R. China.
Zhou'an LiuShaanxi Brain Modulation and Scientific Research Center Xi'an Shaanxi P. R. China.
Xiao YanSchool of Management Xi'an Jiaotong University Xi'an Shaanxi P. R. China.
Hui ZhangState Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research, Center for Dental Materials and Advanced Manufacture, Department of Anesthesiology, School of Stomatology Air Force Medical University Xi'an Shaanxi P. R. China.
Shengxi WuDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine Air Force Medical University Xi'an Shaanxi P. R. China.
Xufeng LiuDepartment of Military Medical Psychology Air Force Medical University Xi'an Shaanxi P. R. China.
Yazhou WangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine Air Force Medical University Xi'an Shaanxi P. R. China.ORCID https://orcid.org/0000-0002-7116-2395

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a group of developmental diseases, which still lacks effective treatments. Pregnant exposure of Valproic acid (VPA) is an important environmental risk factor for ASD, but it's long-term effects on the development of human neural cells, particularly in vivo, and the corresponding treatment have yet been fully investigated. In the present study, we first made a humanized ASD mouse model by transplanting VPA-pretreated human neural progenitor cells (hNPCs) into the cortex of immune-deficient mice. In comparison with wild type and control chimeric mice, ASD chimeric mice (

Indexed as

autism spectrum disorderhumanized mouseprecisely targeted TMSvalproic acid

Identifiers

PMID40385547
PMCPMC12079372

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.