ArticlemedRxiv : the preprint server for health sciences2025
BrainTRACE (Brain Tumor Registration and Cortical Electrocorticography): A Novel Tool for Localizing Electrocorticography Electrodes in Patients with Brain Tumors.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
8 authors.
Funding
Abstract
Background: Intraoperative electrocorticography (ECoG) plays a critical role in clinical care and neuroscience research, enabling precise mapping of functional cortex. However, localizing subdural electrodes in patients with brain tumors presents unique challenges due to altered neuroanatomy and the impracticality of acquiring extraoperative computed tomography (CT). To address this gap, we developed BrainTRACE, a novel MATLAB tool that combines magnetic resonance imaging (MRI), cortical vascular reconstructions, and intraoperative photography for accurate subdural electrode grid placement. Methods: Preoperative MRI, cortical photography, and subdural electrode array data were recorded from patients with diffuse glioma and brain metastasis. BrainTRACE generated three-dimensional cortical surfaces, integrated vascular reconstructions, and enabled precise placement of electrode grids. Each electrode was placed based on cortical anatomy and vascular landmarks informed by intraoperative photographs. Novice and expert-level proficiency were quantified. Results: Expert users achieved high consistency and accuracy, with an intraclass correlation coefficient (ICC) of 0.934 and a mean deviation of 4.3 mm from consensus placements. Novice users demonstrated lower reliability (ICC = 0.399) and greater variability, averaging a 16.3 mm deviation from consensus. These findings highlight the non-trivial nature of intraoperative ECoG localization, which requires neuroanatomical expertise for successful grid placement. Conclusion: BrainTRACE enables accurate localization of intraoperative ECoG electrodes in brain tumor patients. By integrating anatomical images, intraoperative photographs, and vascular mapping, the tool addresses challenges posed by tumor-induced artifacts. While requiring that users have cortical neuroanatomical expertise, BrainTRACE provides a practical tool for neurosurgical and neuroscience applications, including brain malignancy, epilepsy, and deep brain stimulation procedures. BrainTRACE is freely available to researchers (https://github.com/dbrang/BrainTRACE).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.