Evidence map›Paper›PMID 40385416›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Single cell multiomics reveals drivers of metabolic dysfunction-associated steatohepatitis.

Weston Elison, Lei Chang, Yang Xie, Charlene Miciano, Qian Yang, Hannah Mummey, Ryan Lancione, Sierra Corban, Sadatsugu Sakane, Jacinta Lucero and 28 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Weston ElisonBiomedical Sciences program, University of California San Deigo; La Jolla CA.
Lei ChangDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Yang XieDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Charlene MicianoCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Qian YangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Hannah MummeyBioinformatics and Systems Biology program, University of California San Diego; La Jolla CA.
Ryan LancioneCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Sierra CorbanDepartment of Pediatrics, University of California San Diego; La Jolla CA.
Sadatsugu SakaneDepartment of Medicine, University of California San Diego; La Jolla CA USA.
Jacinta LuceroCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Sainath MamdeDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Hyun Young KimDepartment of Medicine, University of California San Diego; La Jolla CA USA.
Matthew J KimDepartment of Pediatrics, University of California San Diego; La Jolla CA.
Rebecca MeltonBiomedical Sciences program, University of California San Deigo; La Jolla CA.
Luca TucciaroneDepartment of Pediatrics, University of California San Diego; La Jolla CA.
Audrey LieDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Timothy LoeDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Tanmayi VashistBiomedical Sciences program, University of California San Deigo; La Jolla CA.
Kelsey DangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Ruth ElgamalBiomedical Sciences program, University of California San Deigo; La Jolla CA.
Daofeng LiDepartment of Genetics, Washington University in St. Louis; St. Louis MO USA.
Melissa VuDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California San Diego, La Jolla, CA.
Elie N FarahDepartment of Medicine, University of California San Diego; La Jolla CA USA.
Chad SengDepartment of Genetics, Washington University in St. Louis; St. Louis MO USA.
Jovina DjulamsahCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Bing YangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Justin BuchananCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Michael MillerCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Mai TranCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Janeth Ochoa BirruetaBiomedical Sciences program, University of California San Deigo; La Jolla CA.
Neil C ChiDepartment of Medicine, University of California San Diego; La Jolla CA USA.
Ting WangDepartment of Genetics, Washington University in St. Louis; St. Louis MO USA.
Agnieszka D'Antonio-ChronowskaCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Allen WangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Deigo; La Jolla CA.
Tatiana KisselevaDepartment of Surgery, University of California San Diego; La Jolla CA USA.
David BrennerDepartment of Medicine, University of California San Diego; La Jolla CA USA.
Bing RenDepartment of Cellular and Molecular Medicine, University of California San Diego; La Jolla, CA.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego; La Jolla CA.

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Transcriptional co-regulators and macrophage gene expressionR01DK091183 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2011 to 2025
$9.9M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
The impact of genomic variation on environment-induced changes in pancreatic beta cell statesU01HG012059 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hannah Kathryn Carter, Kyle Jeffrie Gaulton · 2021 to 2026
$7.5M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Inactivation of Hepatic Stellate Cells During Reversal of Liver FibrosisR01DK099205 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2014 to 2025
$4.8M
The Role of Portal Fibroblasts in Cholestatic Liver FibrosisR01DK101737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2014 to 2025
$3.8M
Novel IL-23 inhibitor for the treatment of alcohol associated liver diseaseU01AA029019 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA, LOOMBA, ROHIT · 2020 to 2024
$3.7M
UC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6M
NCI NIH HHS R01 CA285997NHGRI NIH HHS U01 HG012059NHGRI NIH HHS UM1 HG011585NHLBI NIH HHS T32 HL007444NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA028550NIAAA NIH HHS U01 AA029019NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK091183NIDDK NIH HHS R01 DK099205NIDDK NIH HHS R01 DK101737NIDDK NIH HHS R01 DK111866NIDDK NIH HHS R44 DK115242NIDDK NIH HHS R56 DK088837NIEHS NIH HHS P42 ES010337NIGMS NIH HHS T32 GM008666NIGMS NIH HHS T32 GM145427
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) has limited treatments, and cell type-specific regulatory networks driving MASLD represent therapeutic avenues. We assayed five transcriptomic and epigenomic modalities in 2.4M cells from 86 livers across MASLD stages. Integrating modalities increased annotation of the genome in liver cell types several-fold over previous catalogs. We identified cell type regulatory networks of MASLD progression, including distinct hepatocyte networks driving MASL and mild and severe fibrosis MASH. Our single cell atlas annotated 88% of MASH-associated loci, including a third affecting hepatocyte regulation which we linked to distal target genes. Finally, we characterized hepatocyte heterogeneity, including MASH-enriched populations with altered repression, localization, and signaling. Overall, our results provide high-resolution maps of liver cell types and revealed novel targets for anti-MASH therapy.

Identifiers

PMID40385416
PMCPMC12083587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.