ArticlemedRxiv : the preprint server for health sciences2025
Testing for Causal Association between Serum Urate, Gout, and Prostatic Cancer in European Males.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To conduct a two-sample MR study including only men to test for a causal relationship between serum urate (SU) and gout and prostate cancer. Methods: We used GWAS for SU, gout, and prostate cancer to generate exposure instrumental variables (IV) associated with gout and urate. We used 20 single nucleotide polymorphisms (SNPs) associated with gout but not urate for an IV representing the non-hyperuricemia (inflammatory) compartment of gout and we used four SNPs from loci containing urate transporter genes for an IV representing urate levels. MR methods included inverse-variance-weighted (IVW), MR-Egger regression, and weighted median to test for causal relationships and horizontal pleiotropy. Results: The non-hyperuricemia compartment of gout IV showed a causal effect of gout on prostate cancer (Weighted median: Conclusion: MR analysis in a European male population found evidence for a causal effect between the non-hyperuricemia compartment of gout and prostate cancer. Implication of the
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