Evidence map›Paper›PMID 40385400›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failure.

Yang Xie, Luca Tucciarone, Elie N Farah, Lei Chang, Qian Yang, Thirupura S Shankar, Weston Elison, Shaina Tran, Jovina Djulamsah, Audrey Lie and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Yang XieDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7453-6786
Luca TucciaroneDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0142-2171
Elie N FarahDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-2412-0950
Lei ChangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-2606-3347
Qian YangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Thirupura S ShankarNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Weston ElisonDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Shaina TranDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Jovina DjulamsahCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Audrey LieDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Timothy LoeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Alyssa R HolmanDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Sierra CorbanDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Justin BuchananCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Sainath MamdeDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Haowen ZhouDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Ruth M ElgamalDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Eleni TseliouNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Vincent HuangNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Zhaoning WangDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Jeffery ChiuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Rebecca MeltonDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Emily GriffinDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Qingquan ZhangDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Jacinta LuceroCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Sutip NavankasattusasNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Daofeng LiDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7492-3703
Chanrung SengDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Eugin DesticiDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Craig H SelzmanNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Agnieszka D'Antonio-ChronowskaCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Ting WangDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Allen WangCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Stavros G DrakosNora Eccles Harrison Cardiovascular Research and Training Institute (CVRTI), University of Utah, Salt Lake City, UT, USA.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1318-7161
Bing RenDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5435-1127
Neil C ChiDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-2324-3796

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
The impact of genomic variation on environment-induced changes in pancreatic beta cell statesU01HG012059 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hannah Kathryn Carter, Kyle Jeffrie Gaulton · 2021 to 2026
$7.5M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
UC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6M
Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Mitral RegurgitationR01HL166513 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos · 2023 to 2026
$2.4M
Clinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9M
The Role of Glycosyl Ceramides in Heart Failure and RecoveryK08HL168315 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Eleni Tseliou · 2023 to 2026
$717k
CSRD VA I01 CX002291NHGRI NIH HHS U01 HG012059NHGRI NIH HHS UM1 HG011585NHLBI NIH HHS K08 HL168315NHLBI NIH HHS R01 HL135121NHLBI NIH HHS R01 HL166513NHLBI NIH HHS T32 HL007444NIGMS NIH HHS T32 GM145427
6 · The paper itself

Abstract

Heart failure is a leading cause of morbidity and mortality; yet gene regulatory mechanisms driving cell type-specific pathologic responses remain undefined. Here, we present the cell type-resolved transcriptomes, chromatin accessibility, histone modifications and chromatin organization of 36 non-failing and failing human hearts profiled from 776,479 cells spanning all cardiac chambers. Integrative analyses revealed dynamic changes in cell type composition, gene regulatory programs and chromatin organization, which expanded the annotation of cardiac

Identifiers

PMID40385400
PMCPMC12083629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.