ArticleNuclear medicine and molecular imaging2025
Relationship Between Cerebral Glucose Metabolism and Neurodevelopmental Outcomes in Very-Low-Birth-Weight Infants without Structural Abnormalities.
Article in Nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Very-low-birth-weight (VLBW) infants are more likely to have poor neurodevelopmental outcomes, even if structural abnormalities are not observed during brain magnetic resonance imaging (MRI). The purpose of the present study was to determine whether cerebral glucose metabolism is correlated with neurodevelopmental outcomes in VLBW infants without structural abnormalities. Methods: Twenty-seven VLBW infants (birth weight < 1,500 g) without structural abnormalities were prospectively enrolled. All infants underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) examinations at term-equivalent ages, and the regional glucose metabolic ratios were calculated. Neurodevelopmental outcomes were assessed using the Mental Development Index (MDI) and the Psychomotor Development Index (PDI) of the Bayley Scales of Infant Development-II at a corrected age of 18-24 months. Poor neurodevelopmental outcomes were defined as an MDI or PDI score < 85. Results: The glucose metabolic ratio in the right central region of the brain was significantly correlated with the MDI score ( Conclusions: Cerebral glucose metabolism was correlated with the neurodevelopmental outcomes of VLBW infants at a corrected age of 18-24 months. Supplementary Information: The online version contains supplementary material available at 10.1007/s13139-024-00893-y.
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