ArticleFrontiers in cell and developmental biology2025
Correlation study and full management of metabolic syndrome and sperm DNA fragmentation index, a regional multicentre prospective long term follow-up study from Anhui, China.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Obeticholic Acid Rescues Male Reproductive Function in High-Fat Diet-Induced Metabolic Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Sperm DNA fragmentation: how to test, when to test, and what to do with abnormal results-a pragmatic mini-review for clinical practice.Human reproduction (Oxford, England) · 2026Review
- Long-Term Epidemiological Trends and Regional Disparities in Male Infertility in Central Asia (1991-2023).International journal of environmental research and public health · 2026Article
- Development and validation of a clinical nomogram for predicting cumulative live birth rate in ovarian endometrioma patients undergoing ethanol sclerotherapy andFrontiers in endocrinology · 2026Article
- Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets.International journal of biological sciences · 2025Review
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Abstract
Objective: To investigate the correlation between Metabolic syndrome (Mets) and Sperm DNA fragmentation index (DFI) in men of reproductive age, and to summarise the Mets and metabolic component health management model in men. Methods: The Male Reproductive Health Follow-up Database in Bozhou City, Anhui Province, China (2020-2024) included in the study 1,008 outpatient cases of men with reproductive age,in which normal sperm DFI was the Control group (n = 858) and abnormal DFI was the Observation group (n = 150), and the general data, metabolic endocrine related indicators, and indicators related to fertility assessment were analysed in both groups, and fertility and metabolic indicators were followed up. Spearman rank correlation coefficient was used for correlation analysis, segmented package for threshold analysis, Bootstrap sampling method and Bayesian method for mediation effect test analysis. Univariate-multivariate logistic regression analyses were performed to build a predictive model using R Programming Language (4.42), and to plot the Nomogram, Calibration Curve, Decision Curve Analysis (DCA) Curve, and Clinical impact curve (CIC) to assess the consistency between the predicted probability of the model and the actual occurrence probability, as well as to evaluate the practicality and applicability in clinical decision-making. Results: Intergroup comparison between the observation and control groups in this study showed no statistical difference between the two groups in terms of baseline information and fertility assessment ( Conclusion: MetS may lead to abnormal sperm DNA fragmentation indices, which in turn suggests that abnormal sperm DFI due to MetS may be a risk factor for male infertility and spousal adverse maternity, and that effective interventions to reduce sperm DFI values and metabolic scores are necessary and urgent. This study is part of the China Anhui Regional Male Fertility Survey Phase I (2020-2024).
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