Evidence map›Paper›PMID 40385215›Full record

ArticleACS omega2025

Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,3,4-Thiadiazole Derivatives Targeting Both Aldose Reductase and α-Glucosidase for Diabetes Mellitus.

Betül Kaya, Ulviye Acar Çevik, Adem Necip, Hatice Esra Duran, Bilge Çiftçi, Mesut Işık, Pervin Soyer, Hayrani Eren Bostancı, Zafer Asım Kaplancıklı, Şükrü Beydemir

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Design, Synthesis,Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Betül KayaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, 67600 Zonguldak, Turkey.
Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-1879-1034
Adem NecipDepartment of Pharmacy Services, Vocational School of Health Services, Harran University, 63300 Şanlıurfa, Turkey.
Hatice Esra DuranDepartment of Medical Biochemistry, Faculty of Medicine, Kafkas University, 36100 Kars, Turkey.
Bilge ÇiftçiVocational School of Health Services, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.
Mesut IşıkDepartment of Bioengineering, Faculty of Engineering, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.ORCID https://orcid.org/0000-0002-4677-8104
Pervin SoyerDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Hayrani Eren BostancıDepartment of Biochemistry, Faculty of Pharmacy, Cumhuriyet University, 58140 Sivas, Turkey.ORCID https://orcid.org/0000-0001-8511-2316
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Şükrü BeydemirDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID https://orcid.org/0000-0003-3667-6902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed new 1,3,4-thiadiazole derivatives and examined their ability to inhibit aldose reductase and α-glucosidase. All of the members of the series showed a higher potential of aldose reductase inhibition (

Identifiers

PMID40385215
PMCPMC12079242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.