Evidence map›Paper›PMID 40385210›Full record

ArticleACS omega2025

Rab11 Binding Promotes the p14 FAST Protein-Induced Syncytium Formation.

Shuru Lin, Zhengfei Qi, Quanxiang Yu, Rui Ma, Kexin Zhang, Wenqi Jiang, Yilin Mai, Qingshan Bill Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuru LinCollege of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zhengfei QiShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Quanxiang YuShanghai Institute of Materia Medica, Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Rui MaShanghai Institute of Materia Medica, Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Kexin ZhangShanghai Institute of Materia Medica, Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Wenqi JiangShanghai Institute of Materia Medica, Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Yilin MaiShanghai Institute of Materia Medica, Zhongshan Institute for Drug Discovery, Chinese Academy of Sciences, Zhongshan 528400, China.
Qingshan Bill FuCollege of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-7445-2355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reptile reoviruses encode the p14 fusion-associated small transmembrane (FAST) protein, which induces cell-cell membrane fusion as a nonstructural protein. When the virus enters the host cell, the p14 protein is encoded, synthesized, and delivered to the plasma membrane via the endoplasmic reticulum-Golgi transport system. During this process, the polybasic motif (PBM) at the proximal membrane terminal of the p14 cytosolic endodomain interacts with Rab11 on the Golgi. This interaction places p14 into vesicles enclosed by the AP-1 adaptor, transporting it to the plasma membrane and causing membrane fusion. In this study, we used the surface plasmon resonance principle to confirm that p14

Identifiers

PMID40385210
PMCPMC12079263

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.