Evidence map›Paper›PMID 40385163›Full record

ArticleACS omega2025

Antifungal Structure-Activity Relationship Studies of Broad-Spectrum Phenothiazines.

Samantha C Brosend, Soumitra Guin, Gregory Giovine, Carlos Gadalla, Miguel A Campos, Alisa Mara, Nicholas G Jentsch, Haresh Thakellapalli, Kathryn M Alden, Sarah R Beattie and 2 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha C BrosendDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Soumitra GuinDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.ORCID https://orcid.org/0000-0002-8562-225X
Gregory GiovineDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Carlos GadallaDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Miguel A CamposDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Alisa MaraDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Nicholas G JentschDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Haresh ThakellapalliDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Kathryn M AldenDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.ORCID https://orcid.org/0000-0001-5339-1509
Sarah R BeattieDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.
Damian J KrysanDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.ORCID https://orcid.org/0000-0001-6330-3365
Marvin J MeyersDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.ORCID https://orcid.org/0000-0001-5484-619X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal infections remain a critical unmet medical need with millions of infections occurring annually. With only three classes of antifungal drugs available, drug resistance and modest activity toward some fungi represent threats to human health. To address this, optimization of the antifungal properties of approved drugs with appropriate pharmacokinetic properties represents an attractive strategy. Here, we have shown that the antifungal activity of phenothiazine-based

Identifiers

PMID40385163
PMCPMC12079586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.