Evidence map›Paper›PMID 40385152›Full record

ArticleACS omega2025

Synergistic Inhibition of Colon Cancer Cell Proliferation via p53, Bax, and Bcl-2 Modulation by Curcumin and Plumbagin Combination.

Iftikhar Ahmad, Sameer Ahmad, Md Abdus Samad, Ahmed Mohammed Adam, Torki A Zughaibi, Mahmoud Alhosin, Shazi Shakil, Mohd Shahnawaz Khan, Ahdab A Alsaieedi, Ajoy Kumer and 1 more

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iftikhar AhmadDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Sameer AhmadKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Md Abdus SamadDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed Mohammed AdamDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Torki A ZughaibiKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mahmoud AlhosinDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Shazi ShakilDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mohd Shahnawaz KhanProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0002-4599-5924
Ahdab A AlsaieediKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ajoy KumerDepartment of Chemistry, College of Arts and Sciences, International University of Business Agriculture & Technology (IUBAT), Dhaka 1230, Bangladesh.ORCID https://orcid.org/0000-0001-5136-6166
Shams TabrezKing Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID https://orcid.org/0000-0003-4550-415X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a major contributor to global morbidity and mortality. Among the different forms of cancer, colorectal cancer (CRC) is the third most frequently diagnosed cancer in men and the second most common cancer type in women globally. We aimed to explore the possible synergistic anticancer potential of curcumin (Cur) and plumbagin (PL) in the human colon cancer cell line (HCT-116). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)/cytotoxicity assay revealed IC

Identifiers

PMID40385152
PMCPMC12079253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.