ArticleACS omega2025
Phenanthroline-Assisted Stereoselective Synthesis of 2-Deoxy Glycosides.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
The significance of 2-deoxy glycosides in biologically active compounds is well-established, as they frequently play a pivotal role in modulating the efficacy of therapeutic agents. The 2-deoxy sugar embodies a distinctive class of carbohydrates characterized by marked differences in stability, reactivity, and selectivity compared to their counterparts bearing C2-oxygen or other heteroatoms. As a result, the stereoselective synthesis of this carbohydrate class is complicated by its sensitivity to acidic conditions and propensity for hydrolysis and elimination reactions. Furthermore, the lack of C2-oxygen functionality presents an additional challenge in controlling stereoselectivity. In this study, we report the application of commercially available phenanthroline as an effective additive in the stereoselective glycosylation of aliphatic alcohols and phenolic nucleophiles with 2-deoxy glycosyl chlorides, facilitating efficient access to a variety of α-2-deoxy glycosides in high yields with synthetically useful stereoselectivity. Kinetic analyses suggest that phenanthroline plays a crucial role in modulating the selectivity of the reaction.
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