ReviewAmerican journal of translational research2025
Research progress on the role of Claudin family proteins in mediating blood-brain barrier selective permeability in tumor metastasis.
Review in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Characterization of Oncogenic and Immunogenic Profiling in Patients with Breast Cancer Tumors After Radiation Therapy.International journal of molecular sciences · 2026Article
- [Plasma metabolites mediates the causal effect of inflammatory proteins on Alzheimer's disease: a Mendelian randomization study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood-brain barrier (BBB) serves as a critical protective mechanism for the central nervous system (CNS), controlling the selective passage of molecules between the brain and the bloodstream. Claudin proteins, key components of tight junctions, play a central role in maintaining BBB integrity and regulating its permeability. Recent research has increasingly focused on how Claudins contribute to brain metastasis, where tumor cells alter Claudin expression to breach the BBB and invade brain tissue. While Claudin family such as Claudin-1 and Claudin-5 are essential for maintaining BBB function, their dysregulation in tumor cells facilitates BBB disruption, promoting metastasis. This review explores the dual role of Claudins in tumor progression, detailing how they regulate BBB permeability and enable tumor cells to cross the barrier. Additionally, we discuss the potential of Claudin proteins as therapeutic targets in cancer treatment, offering new insights into mechanisms of brain metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.