ArticleAmerican journal of translational research2025
Risk factors for persistent infection of high-risk HPV in patients with cervical intraepithelial neoplasia.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Interoperability of two commercial kits in detecting high oncogenic human papilloma virus and genetic diversity in Cameroon: implications for cervical cancer screening strategies in resource-limited settings.Infectious agents and cancer · 2026Article
- Association of Oral Papivir/PavironaViruses · 2026Article
- Association Between HPV Vaccination and Cervical Dysplasia Severity in HPV-Positive Women.Diagnostics (Basel, Switzerland) · 2026Article
- An Overview of the Mechanisms of HPV-Induced Cervical Cancer: The Role of Kinase Targets in Pathogenesis and Drug Resistance.Cancers · 2026Review
- Local carboxymethyl β-glucan and polycarbophil in women positive for human papillomavirus: a prospective observational study.Drugs in context · 2026Article
- Cervical Cancer Screening in Transition: Global Challenges and Local Realities.International journal of women's health · 2026Review
- Risk factors for HR-HPV persistence and residual or recurrent high-grade squamous intraepithelial neoplasia after LEEP.Frontiers in medicine · 2026Article
- Investigation of the Prevalence of High-Risk Human Papillomavirus, Human Herpesvirus-8, and Herpes Simplex Virus-2 in Cervical Biopsy Samples Using the Real-Time PCR Method.Tropical medicine and infectious disease · 2025Article
- Clinical characteristics and treatment outcomes of cervical high-grade squamous intraepithelial lesions in women under 25 years: a retrospective cohort study.Frontiers in oncology · 2025Article
- HPV Prevention in Men: A Narrative Review of Strategies, Risks, and Public Health Implications.American journal of men's healthReview
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3 authors.
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Abstract
objectiveTo identify the risk factors for persistent HR-HPV infection in patients with cervical intraepithelial neoplasia (CIN).
methodsA total of 312 patients with cervical intraepithelial neoplasia were followed up for six months. Among them, 164 patients with persistent HPV infection during re-examination were categorized into the persistent infection group, while 148 patients with negative HPV results were classified into the negative conversion group.
resultsMultivariate logistic regression analyses identified the following independent risk factors for persistent HR-HPV infection: age ≥50 years (95% CI: 3.037-11.447; P<0.001), multiple HPV infections (95% CI: 4.250-18.417; P<0.001), HPV viral load ≥100 (95% CI: 1.529-5.673; P=0.001), reproductive tract inflammation (95% CI: 1.186-4.696; P=0.014), and thyroid dysfunction (95% CI: 8.346-17.207; P<0.001). A prediction model was developed based on the logistic regression analysis: Logit(P) = -102.56 + (age × 1.774) + (HPV multiple infections × 2.180) + (HPV viral load ≥100 × 1.080) + (reproductive tract inflammation × 0.859) + (thyroid dysfunction × 3.650). Receiver operating characteristic (ROC) curve analysis showed an area under the curve (AUC) of 0.800 for the model in predicting persistent high-risk HPV infection, with sensitivity of 81.00% and specificity of 79.46%.
conclusionAge ≥50 years, multiple HPV infections, HPV viral load ≥100, reproductive tract inflammation, and thyroid dysfunction are independent risk factors for persistent high-risk HPV infection in patients with CIN.
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