ArticleAmerican journal of translational research2025
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dynamics of neural plasticity.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits inbioRxiv : the preprint server for biology · 2025Article
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3 authors.
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Abstract
objectivesTo investigate gene expression dynamics in adult primate neocortex and elucidate the molecular basis of these capabilities.
methodsWhole-cell transcriptome data from primary visual cortex (V1) of cynomolgus monkeys were analyzed, focusing on inhibitory neurons derived from the medial ganglionic eminence. Using RNA velocity and scVelo algorithms, we investigated subtle gene expression shifts, identified key driver genes, and conducted functional enrichment analysis.
resultsOur analysis revealed that somatostatin (
conclusionsThis study provides novel insights into the gene expression dynamics of the primate neocortex. Genes involved in neuronal development and plasticity may underlie the advanced information-processing capabilities in primates.
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