ArticleAmerican journal of translational research2025
Factors influencing the diagnostic accuracy of lung cancer using endobronchial ultrasound-guided transbronchial needle aspiration.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Cryobiopsy Outperforms Fine-Needle Aspiration for Mediastinal Lymphadenopathy: A Within-Patient Diagnostic Accuracy Study and Clinical Predictors of Success.Journal of clinical medicine · 2026Article
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8 authors.
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Abstract
objectivesEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a key diagnostic modality for lung cancer, yet its accuracy varies based on several factors. This study aims to identify factors influencing the diagnostic accuracy of EBUS-TBNA for lung cancer detection.
methodsA retrospective case-control study was conducted on lung cancer patients diagnosed at Gaozhou People's Hospital from October 2021 to September 2023. Patients with lung cancer confirmed by EBUS-TBNA, bronchoscopy with direct biopsy, or surgical intervention were re-evaluated using EBUS-TBNA. Based on diagnostic accuracy, they were classified into an accurate group (n = 204) and an inaccurate group (n = 41). An external validation cohort included 58 lung cancer patients. Data collection encompassed patient demographics and EBUS-TBNA findings. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to determine factors influencing detection accuracy. A generalized linear model incorporating independent influencing factors was developed to estimate the likelihood of inaccurate EBUS-TBNA detection of lung cancer.
resultsSmoking history [dds ratio (OR), 7.948;
conclusionSmoking history, pathologic subtype, lesion size and aspirate sample characteristics significantly affected the diagnostic accuracy of EBUS-TBNA in lung cancer detection. These insights underscore the importance of considering these factors in clinical practice to optimize EBUS-TBNA's diagnostic performance.
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