ArticleAmerican journal of translational research2025
Correlation between ultrasound measurements and the expression of Her-2 and CD147 in breast cancer.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo analyze the correlation between ultrasound data and Her-2 and CD147 expressions in breast carcinoma.
methodA retrospective analysis was conducted on 95 patients with invasive breast carcinoma, hospitalized during March 2021 to May 2024, designated as the breast cancer group. Additionally, 80 cases with benign breast lesions were selected as the control group. Contrast-enhanced ultrasound (CEUS) was performed on both groups. Immunohistochemistry was used to detect the expression of Her-2 and CD147 proteins in breast cancer and adjacent tissues, while RT-qPCR was employed to measure the mRNA expression of Her-2 and CD147 in the cancer and adjacent tissues.
resultsThe peak time in the breast cancer group was shorter than in the control group (
conclusionThe contrast-enhanced ultrasound data of malignant breast tumors significantly differed from those of benign tumors, demonstrating good diagnostic value for breast cancer. In addition, these ultrasound data were significantly correlated with the expression of Her-2 and CD147 in tumor tissues, providing valuable insight for the non-invasive assessment of early-stage breast cancer and offering a reference for diagnosis and treatment planning.
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