ArticleAmerican journal of translational research2025
Efficacy of allylestrenol combined with ritodrine in treating preterm labour with preeclampsia and associated risk factors for pregnancy outcomes.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the efficacy of diethylstilbestrol combined with ritodrine in treating preterm labor due to preeclampsia and to identify risk factors for different pregnancy outcomes.
methodsA retrospective cohort study was conducted on 112 preterm pregnant women treated at Maanshan Maternal and Child Health Care Hospital from January 2022 to December 2023. Patients were divided into an observation group (n = 60) receiving allylestrenol tablets (10 mg daily, reduced to 5 mg after contractile reaction disappeared) and ritodrine injection (100 mg in 500 mL sedative, infused at 0.05-0.35 mg/min for 12-18 hours), and a control group (n = 52) treated with magnesium sulfate injection. Measured outcomes included symptom score, gestational age at delivery, treatment efficacy, adverse reactions, blood magnesium (MG), serum progesterone-induced blocking factor (PIBF), interleukin-6 (IL-6), cervical length (CL), and fetal fibronectin (fFN) levels.
resultsThe observation group had a significantly higher effective rate (78%) compared to the control group (54%, χ
conclusionsAllylestrenol combined with ritodrine is effective for managing preterm labor due to preeclampsia, improving maternal and fetal outcomes with good safety. This treatment warrants further clinical application.
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