ArticleAmerican journal of translational research2025
Sacubitril/valsartan combined with amiodarone enhances cardiac function and reduces adverse outcomes in patients with new-onset atrial fibrillation after acute myocardial infarction.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the efficacy of amiodarone alone versus amiodarone combined with sacubitril/valsartan in patients with new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) and to provide a theoretical basis for optimizing clinical strategies.
methodsData of 106 NOAF patients admitted to West China Hospital, Sichuan University (January 2022 to June 2024) were retrospectively analyzed. Patients were divided into a control group (amiodarone alone) and an observation group (amiodarone combined with sacubitril/valsartan). Demographic characteristics, length of hospital stay, duration of atrial fibrillation, creatine kinase MB (CK-MB), high-sensitivity cardiac troponin T (hs-cTnT), ventricular rate, creatinine, urea, C-reactive protein (CRP), alanine transaminase (ALT), and aspartate aminotransferase (AST) were collected and compared between the two groups. Cardiac function parameters, including left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), recurrence rate, and other adverse events, were recorded at admission and six months post-discharge.
resultsBoth groups showed significant improvement in CK-MB, hs-cTnT, ventricular rate, ALT, and AST after treatment, with no significant difference between the groups. While CRP levels remained stable in the control group, the observation group demonstrated a significant decrease. Additionally, the observation group showed a significantly elevated LVEF level but lower LVESD and LVEDD levels after treatment, while these parameters remained unchanged in the control group. Besides, the observation group had a longer recurrence time and a lower incidence of stroke.
conclusionAmiodarone combined with sacubitril/valsartan significantly improves cardiac function, prolongs the time to recurrence, and reduces the incidence of stroke in NOAF patients after AMI.
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