Evidence map›Paper›PMID 40385029›Full record

ArticleAmerican journal of translational research2025

ITGA5 promotes cervical cancer progression by regulating IMP3 recruitment of HK2 mRNA.

Liuxuanning Zhou, Yue Liu, Yan Zhang, Fan Hu, Lu Shen, Shunyu Hou

Abstract read
In one paragraph

Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liuxuanning ZhouDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital No. 26, Daoqian Street, Suzhou 215002, Jiangsu, China.
Yue LiuDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital No. 26, Daoqian Street, Suzhou 215002, Jiangsu, China.
Yan ZhangDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital No. 26, Daoqian Street, Suzhou 215002, Jiangsu, China.
Fan HuState Key Laboratory of Reproductive Medicine and Offspring Health, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Lu ShenDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital No. 26, Daoqian Street, Suzhou 215002, Jiangsu, China.
Shunyu HouDepartment of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou Municipal Hospital No. 26, Daoqian Street, Suzhou 215002, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is a prevalent gynecologic malignancy characterized by high rates of invasion and metastasis. Integrin alpha 5 (ITGA5), a member of the integrin family, has been implicated in tumor progression; however, its regulatory role in cervical cancer remains poorly defined. Bioinformatic analyses revealed elevated ITGA5 expression in cervical cancer, which was further validated in patient tissues by immunohistochemistry (IHC). ITGA5 was either silenced or overexpressed in cervical cancer cell lines, and its effects on proliferation, invasion, and migration were assessed using CCK-8, Transwell, and wound healing assays. The

Indexed as

Cervical cancerHK2IMP3integrinITGA5

Identifiers

PMID40385029
PMCPMC12082524

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.