ArticleAmerican journal of translational research2025
Expression of transient receptor potential vanilloid type 1 (TRPV1) in colonic mucosa of patients with irritable bowel syndrome.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
objectiveTo investigate the expression pattern of the transient potential vanilloid type 1 (TRPV1) in the colonic mucosa of patients with irritable bowel syndrome (IBS), its clinical manifestations, and possible pathways of action.
methodsThis study included 80 IBS patients (IBS group) diagnosed at The Second Affiliated Hospital of Soochow University from 2013 to 2017, and 60 healthy examinees as controls (N group). All participants underwent colonoscopy and the results were normal. Colonic mucosal tissue was obtained through biopsy and paraffin sectioned for routine pathologic evaluation. Immunohistochemistry was used to detect the expression of TRPV1, and its correlation with IBS symptoms was analyzed.
resultsThe expression of TRPV1 in the IBS group (0.8, 0-8.4) was significantly higher than that of the control group (0.4, 0-1) (
conclusionTRPV1 expression in the colonic mucosa of IBS patients is elevated and positively correlated with symptom severity. However, no significant differences were found in TRPV1 expression among patients with different IBS subtypes or between genders. The expression of TRPV1 was abnormal in the mucosa of ascending and descending colon, but the difference was not statistically significant.
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