ArticleAmerican journal of translational research2025
Montelukast sodium combined with levocabastine nasal spray demonstrates high efficacy in treating pediatric allergic rhinitis.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of montelukast on allergic rhinitis in children: a systematic review and meta-analysis.American journal of translational research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the efficacy and safety of montelukast sodium (MKS) combined with levocabastine (LEVO) nasal spray in treating pediatric allergic rhinitis and its impact on quality of life (AR).
methodsA total of 125 pediatric AR patients, diagnosed between September 2022 and September 2024, were enrolled and divided into two groups. The research group (n = 65) received MKS plus LEVO nasal spray, while the control group (n = 60) received LEVO nasal spray alone. Treatment efficacy, safety (assessing xerostomia, headache, and gastrointestinal disturbances), and clinical symptom scores (rhinorrhea, sneezing, nasal obstruction, and nasal pruritus) were evaluated. Additionally, nasal cavity parameters (nasal resistance (NR), minimum cross-sectional area (mCSA), and nasal cavity volume (NCV)), serum inflammatory markers (IL-4, IL-8, IL-10), serum biochemical indices (total immunoglobulin E [TlgE], eosinophil count [EOS], eosinophil cationic protein [ECP]), and quality of life (Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ]) were analyzed. Univariate and multivariate binary logistic regression analyses were conducted to identify factors influencing treatment outcomes.
resultsThe research group demonstrated significantly higher overall treatment efficacy than the control group (P<0.05), with a comparable safety profile (P>0.05). Post-treatment, clinical symptom scores, IL-4, IL-8, TlgE, EOS, ECP levels and RQLQ scores were significantly reduced in the research group compared to the control group (all P<0.05). Conversely, IL-10 levels were significantly higher in the research group (both P<0.05). Notably, passive secondhand smoke exposure, IL-10, EOS, and treatment modality were significantly associated with treatment efficacy (all P<0.05). Binary logistic regression identified passive secondhand smoke exposure (P = 0.035) and EOS (P = 0.036) as independent risk factors for treatment outcomes.
conclusionsThe combination of MKS and LEVO nasal spray demonstrates superior efficacy and safety in pediatric AR treatment, significantly improving patients' quality of life. Moreover, treatment failure is closely linked to passive secondhand smoke exposure and elevated EOS levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.