Evidence map›Paper›PMID 40384949›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2025

Heart Rate Recovery After Cardiopulmonary Exercise Test Predicts Acute Exacerbations in Patients with Moderate Chronic Obstructive Pulmonary Disease.

Shan Nie, Ailin Yang, Wei Yuan, Nan Jia, Yunxiao Li, Yue Yu, Bo Xu, Qiufen Xu, Haoyan Wang, Xin He

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shan Nie *Department of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Ailin Yang *Department of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Wei YuanDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Nan JiaDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Yunxiao LiDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Yue YuDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Bo XuDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Qiufen XuDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.
Haoyan WangDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.ORCID 0000-0003-3267-8396
Xin HeDepartment of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, People's Republic of China.

Funding

Capital’s Funds for Health Improvement and Researc 2018-2-2-24Capital’s Funds for Health Improvement and Researc 2024-2-1101Key Clinical Specialty Construction Program of Beijing 2020–2022National Nature Science Foundation of China 81700038National Nature Science Foundation of China 81870029
6 · The paper itself

Abstract

Background: Automatic dysfunction is present in patients with Chronic Obstructive Pulmonary Disease (COPD). Heart rate recovery at 1 min (HRR1) after Cardiopulmonary Exercise Testing (CPET) serves an indicator of automatic function. Despite its potential significance, this primary method is still not well understood or widely utilized in predicting the progression of COPD. This study aimed to determine whether this indicator predicts acute exacerbations of COPD (AECOPD). Methods: In this prospective cohort study, 62 patients with COPD were recruited from 2013 to 2017. All participants underwent CPET test and followed up for 5 years thereafter. Univariate and multivariate linear regression, as well as Cox regression, were utilized to identify the abnormal HRR1 and the variables influencing AECOPD. Results: HRR1 after CPET was a significant correlation of COPD progression. According to the Receiver Operating Characteristic curve, 14 beats/min for HRR1 was optimally used to measure the characteristics of COPD patients. HRR1≤14 beats/min significantly predicted the time to the first AECOPD ( Conclusion: HRR1 after CPET was an independent predictor of AECOPD. Thus, this index can be applied to observe the conditions and treatment results of COPD patients.

Indexed as

Exercise TestExercise ToleranceHeart RateLungPulmonary Disease, Chronic ObstructiveAgedDisease ProgressionFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRecovery of FunctionRisk Factorsautonomic dysfunctioncardiopulmonary exercise testCOPDexacerbationsheart rate recovery

Identifiers

PMID40384949
PMCPMC12083485

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.