ArticleJournal of mood and anxiety disorders2025
Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.
Article in Journal of mood and anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02807480 (Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response
Who cites it
2 citing papers in PubMed.
- Reward processing differences in autism: current understandings and future directions.Social cognitive and affective neuroscience · 2026Review
- Social well-being moderates behavioral therapy response for generalized anxiety disorder.Journal of mood and anxiety disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Aberrant reward processing has been predominantly associated with depressive disorders, with evidence that pre-treatment abnormalities in striatal reward responsiveness relates to treatment outcomes. Emerging research also implicates reward processing differences in anxiety disorders, particularly generalized anxiety disorder (GAD). The current study examined whether pre-treatment reward- and loss-related neural activity predicts symptom improvement with behavioral activation (BA) and exposure therapy (EXP) for GAD. In this randomized clinical trial (ClinicalTrials.gov NCT02807480) conducted from 2016 to 2021, treatment-seeking adults with GAD completed the monetary incentive delay task during functional magnetic resonance imaging pre-treatment, then were randomized to 10-session EXP or BA. The primary outcome measure was the GAD-7. Of 101 participants consented, 69 completed treatment, the 46 completers with quality imaging data were included in analyses (22 EXP, 24 BA; mean 32.7 years, 10.9 % male).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.