Evidence map›Paper›PMID 40384935›Full record

ArticleiScience2025

A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation.

Shuya Wang, Xianlei Sun, Qingxuan Xin, Jianxiang Shi, Jin Li, Huilin Zhang, Mengjiao Xue, Fanxiang Yin, Zan Qiu, Xiaoqian Wang and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shuya WangDepartment of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xianlei SunBasic Medical Research Center, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Qingxuan XinDepartment of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Jianxiang ShiPrecision Medicine Center, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Jin LiTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Huilin ZhangTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Mengjiao XueTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Fanxiang YinTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zan QiuPrecision Medicine Center, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xiaoqian WangDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Nannan SunDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yingmei LiDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yaoyao ChenDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Liyan FuDepartment of Laboratory Medicine, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Chaoqi LiTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shaohua YanTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xian ZhaoTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Bolin JueXinxiang Medical University College of Basic Medical Sciences, Xinxiang, Henan, China.
Yanxia GaoDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Baohong YueDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Bo QinTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yong JiangState Key Laboratory of Antiviral Drugs, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Rongqun GuoTranslational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilson disease (WD) is caused by mutations of the copper-transporting gene,

Indexed as

Biological sciencesImmune responseImmune systemImmune system evolutionImmunologyTranscriptomics

Identifiers

PMID40384935
PMCPMC12084004

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.