ReviewInternational journal of biological sciences2025
Sepsis-associated encephalopathy: Mechanisms, Diagnosis, and Treatments update.
Review in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk prediction models for sepsis-associated encephalopathy: a systematic evaluation and meta-analysis.PeerJ · 2026Pooled it
- TREM2 Attenuates Microglial Pyroptosis in Sepsis-Associated Encephalopathy Through Modulation of the mtDNA-cGAS-STING Pathway.Molecular neurobiology · 2026Article
- Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.Clinics (Sao Paulo, Brazil) · 2026Article
- Improving the Outcome of Brain-Injured Patients by Non-Continuous Feeding to Prevent Dysbiosis.Nutrients · 2026Review
- Associations between pneumonia with sepsis, sepsis-associated encephalopathy, and mortality in adult intensive care unit: a retrospective analysis using MIMIC-IV database.Journal of thoracic disease · 2026Article
- Astrocytic LCN2 mediates pathological crosstalk with neurons to promote neuronal loss in sepsis-associated encephalopathy.Cell death and differentiation · 2026Article
- Serum AIM2 as a Prognostic Biomarker for Disease Severity and Delirium in Acute Pancreatitis: A Multicenter Prospective Cohort Study.Brain and behavior · 2026Article
- Admission 25-Hydroxyvitamin D Deficiency Is Associated with Poor Outcomes in ICU Patients with Sepsis-Associated Encephalopathy (SAE).Journal of clinical medicine · 2026Article
- Hydrogen alleviates sepsis-associated encephalopathy via ATG9B-dependent mitophagy.Molecular medicine (Cambridge, Mass.) · 2026Article
- Ulinastatin Treatment Associated with Lower Sepsis-Associated Encephalopathy Risk in Sepsis Patients: A Multicenter Observational Study.Shock (Augusta, Ga.) · 2026Observational
- Association between prognostic nutritional index and mortality in patients with sepsis-associated delirium: a retrospective cohort study using the MIMIC-IV database.BMC nutrition · 2026Article
- M2 microglial exosomal miR-1949 ameliorates sepsis-associated encephalopathy through DKK1/Wnt/β-catenin-mediated microglial repolarization.Archives of pharmacal research · 2026Article
- Impact of prenatal LPS on sepsis-related neurobiological outcomes.Metabolic brain disease · 2026Article
- Clinical Significance of Serum Soluble Klotho Levels in Sepsis-Associated Encephalopathy: A Single-Center Prospective, Preliminary Study.Journal of clinical medicine · 2026Article
- Association between the monocyte-to-lymphocyte ratio and 28-day all-cause mortality in sepsis-associated delirium patients: a retrospective study and machine learning.BMC infectious diseases · 2026Article
- Endothelial-specific Ezh2 deficiency exacerbates blood-brain barrier dysfunction and neuroinflammation in sepsis-associated encephalopathy.Journal of neuroinflammation · 2026Article
- Neurological Complications in Intensive Care Units: From Delirium to Long-Term Cognitive Dysfunction-A Narrative Review.Journal of clinical medicine · 2026Review
- Endothelial miR-7052 Safeguards Blood-Brain Barrier Integrity During Endotoxemia by Co-repressing ANGPT2 and PDE5A.Molecular neurobiology · 2026Article
- Liraglutide alleviates sepsis-associated encephalopathy via attenuating neuronal damage, glial cell activation and mitochondrial dysfunction in a mouse model of sepsis.European journal of medical research · 2026Article
- [Epidemiology, Mechanisms, and Clinical Challenges of Respiratory Syncytial Virus Co-infections in Children].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis-associated encephalopathy (SAE) is defined as a syndrome of cerebral dysfunction secondary to sepsis but in the absence of direct central nervous system infection, structural abnormality, or other types of encephalopathy. The majority of clinical studies indicated that the severity and duration of SAE were highly related to the days of ICU stays, medical costs, and mortality of sepsis. Meanwhile, the persistence of cognitive impairments and psychological diseases in a majority of survived septic patients brings a heavy burden on those individuals and society. However, the pathogenesis of SAE has not been fully elucidated. A valid and unified diagnosis protocol, as well as effective remedy are still absent. The purpose of this narrative review is to discuss and update the current understanding of the clinical manifestations and risk factors, the recent findings and potential perspectives for the mechanism research, diagnostic methods, and treatments for SAE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.