ReviewInternational journal of biological sciences2025
Control of Snail1 protein stability by post-translational modifications: the basis for a complex regulation of Snail1 function.
Review in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Decoding epithelial-mesenchymal transitions with multi-omics.Nature reviews. Genetics · 2026Review
- A Disorder-Aware Computational Framework to Identify Structurally Tractable Targets in Proliferative Vitreoretinopathy.Ophthalmology science · 2026Article
- Hijacking the Host: Post-Translational Modifications as Molecular Switches in HIV Persistence and Immune Evasion.Journal of medical virology · 2026Review
- Pancreatic cancer EMT‑targeted therapy: Molecular mechanisms and clinical translation (Review).International journal of oncology · 2026Review
- Apicobasal Polarity Protein PARD3 Plays an Essential Role in Human Corneal Epithelial Cells.Investigative ophthalmology & visual science · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Snail1 transcriptional factor is essential for the epithelial to mesenchymal transition and for the acquisition by tumor cells of properties associated to this transition, such as increased invasion and chemoresistance. Snail1 function is mainly controlled post-translationally, through different modifications that directly or indirectly control Snail1 protein stability. In this review I describe these modifications, the enzymes that produce them and their relevance for Snail1 function, focusing particularly in polyubiquitination and phosphorylation. I also propose several explanations for the divergent effects of some of these modifications, since the phosphorylation of some residues have been reported to both promote and decrease Snail1 stability. Moreover, I discuss the possible causes of the observed Snail1 promiscuity in the interaction with the many factors involved in its regulation, on the basis of the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.