Evidence map›Paper›PMID 40384860›Full record

ArticleInternational journal of biological sciences2025

N-acetylcysteine and raloxifene boost photodynamic therapy against cutaneous squamous cell carcinoma by decreasing TGFβ1 secreted by cancer-associated fibroblasts.

María Gallego-Rentero, Luisa María Botella, Marta Mascaraque, Jimena Nicolás-Morala, Virginia Albiñana, Edgar Abarca-Lachen, Yolanda Gilaberte, Salvador González, Ángeles Juarranz, Elisa Carrasco

Abstract read
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cytokines and cancer-associated fibroblasts.Journal of hematology & oncology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

María Gallego-RenteroDepartamento de Biología, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Luisa María BotellaCentro de Investigaciones Biológicas Margarita Salas | CSIC, 28040, Madrid, Spain.
Marta MascaraqueLa Paz Hospital, 28029, Madrid, Spain.
Jimena Nicolás-MoralaDepartamento de Biología, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Virginia AlbiñanaCentro de Investigaciones Biológicas Margarita Salas | CSIC, 28040, Madrid, Spain.
Edgar Abarca-LachenFacultad de Ciencias de la Salud, Universidad de San Jorge, 22300, Barbastro, Spain.
Yolanda GilaberteServicio de dermatología, Miguel Servet Hospital, 50009, Zaragoza, Spain.
Salvador GonzálezDepartment of Medicine and Medical Specialties, Alcalá de Henares University, 28805, Madrid, Spain.
Ángeles JuarranzDepartamento de Biología, Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Elisa CarrascoDepartamento de Biología, Universidad Autónoma de Madrid, 28049, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent skin cancer. While surgery remains the gold standard treatment, non-invasive methods like photodynamic therapy (PDT) stand out for their high efficacy and minimal cosmetic impact. However, resistance to PDT is still a challenge. Numerous cellular processes involved in cancer biology and therapy resistance are regulated by the TGFβ1/SMAD pathway. Using

Indexed as

AcetylcysteineCancer-Associated FibroblastsCarcinoma, Squamous CellPhotochemotherapyRaloxifene HydrochlorideSkin NeoplasmsTransforming Growth Factor beta1AnimalsCell Line, TumorHumansMiceAcetylcysteineRaloxifene HydrochlorideTransforming Growth Factor beta1cell cycle arrestcutaneous squamous cell carcinomaendoglinN-acetylcysteinephotodynamic therapyraloxifeneTGFβ1

Identifiers

PMID40384860
PMCPMC12080389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.