ArticleInternational journal of biological sciences2025
Theaflavins attenuate iron overload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis.
Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Spermidine Alleviates Liver Damage Induced by Iron Overload by Inhibiting Oxidative Stress.Biological trace element research · 2026Article
- Protective Effects of Nongxiang-TypeFood science & nutrition · 2026Article
- Theaflavins counteract free fatty acid-driven oxidative-inflammatory injury in endothelial cells through Nrf2-NF-κB axis.Frontiers in immunology · 2026Article
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11 authors.
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Abstract
Liver, as a major iron storage organ, is particularly sensitive to oxidative stress-induced damage stemming from iron overload. Thus, antioxidant therapies are often used to reverse oxidative stress-induced tissues damage, however, the cellular mechanisms remain enigmatic. This study investigated the protective effects and mechanisms of theaflavins, a nature production from tea, against oxidative damage in iron overload hepatocytes and mouse liver. Iron overload disrupted iron metabolism in hepatocytes by activating inflammation and enhancing HO-1 expression, leading to hepatic ferroptosis and serious liver damage. Additionally, iron overload inhibited Xc
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