Evidence map›Paper›PMID 40384788›Full record

ArticleRSC chemical biology2025

Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms.

Monica S Hensley, David Hutchings, Aldelrahman Ismail, Marina Tanasova

Erratum issuedAbstract read
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Monica S HensleyDepartment of Chemistry, Michigan Technological University 1400 Townsend Dr Houghton MI 49931 USA mtanasov@mtu.edu.
David HutchingsDepartment of Chemistry, Michigan Technological University 1400 Townsend Dr Houghton MI 49931 USA mtanasov@mtu.edu.
Aldelrahman IsmailDepartment of Chemistry, Michigan Technological University 1400 Townsend Dr Houghton MI 49931 USA mtanasov@mtu.edu.
Marina TanasovaDepartment of Chemistry, Michigan Technological University 1400 Townsend Dr Houghton MI 49931 USA mtanasov@mtu.edu.ORCID https://orcid.org/0000-0003-4771-9533

Funding

Molecular probes for targeting facilitative fructose transporters (GLUTs) in biochemical and biomedical applicationsR15CA242401 · NCI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI TANASOVA, MARINA · 2019 to 2024
$902k
NCI NIH HHS R15 CA242401
6 · The paper itself

Abstract

The direct link between sugar uptake and metabolic diseases highlights the iminent need for molecular tools to detect and evaluate alterations in sugar uptake efficiency as approaches to identify disease-relevant metabolic alterations. However, the strict requirements of facilitative glucose transporters regarding substrate binding and translocation pose challenges for developing effective fluorescence molecular probes. Based on the state-of-the-art understanding of glucose recognition by facilitative transporters (GLUTs), we designed a glucopyranoside mimic - GluRho - that delivers the "turn-on" rhodamine B to live cells

Identifiers

PMID40384788
PMCPMC12080487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.