Evidence map›Paper›PMID 40384787›Full record

ArticleRSC chemical biology2025

Exploring sequence- and structure-based fitness landscapes to enhance thermal resistance and activity of endoglucanase II with minimal experimental effort.

Atul Kumar, Alexander-Maurice Illig, Nicolas de la Vega Guerra, Francisca Contreras, Mehdi D Davari, Ulrich Schwaneberg

Abstract read
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Atul KumarLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3 52074 Aachen Germany u.schwaneberg@biotec.rwth-aachen.de.ORCID https://orcid.org/0009-0005-0560-8802
Alexander-Maurice IlligLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3 52074 Aachen Germany u.schwaneberg@biotec.rwth-aachen.de.
Nicolas de la Vega GuerraLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3 52074 Aachen Germany u.schwaneberg@biotec.rwth-aachen.de.
Francisca ContrerasLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3 52074 Aachen Germany u.schwaneberg@biotec.rwth-aachen.de.
Mehdi D DavariDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3 06120 Halle Germany.ORCID https://orcid.org/0000-0003-0089-7156
Ulrich SchwanebergLehrstuhl für Biotechnologie, RWTH Aachen University, Worringerweg 3 52074 Aachen Germany u.schwaneberg@biotec.rwth-aachen.de.ORCID https://orcid.org/0000-0003-4026-701X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancing the performance of cellulases at high temperatures is crucial for efficient biomass hydrolysis-a fundamental process in biorefineries. Traditional protein engineering methods, while effective, are time-consuming and labour-intensive, limiting rapid advancements. To streamline the engineering process, we tested two distinct

Identifiers

PMID40384787
PMCPMC12080268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.