ArticleMagnetic resonance (Gottingen, Germany)2024
Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform.
Article in Magnetic resonance (Gottingen, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Combining photo-CIDNP and long-lived spin states enables high-contrast detection of weak protein-ligand interactions.Physical chemistry chemical physics : PCCP · 2026Article
- Continuous-Wave (CW) Photo-CIDNP NMR Spectroscopy: A Tutorial.Magnetic resonance in chemistry : MRC · 2025Article
- Investigation of Methionine Metabolism in Coccolithophore byThe journal of physical chemistry letters · 2025Article
- Rapid Protein-Ligand Affinity Determination by Photoinduced Hyperpolarized NMR.Journal of the American Chemical Society · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in NMR fragment screening use sample illumination to boost NMR sensitivity, reduce measurement time to a few seconds, and reduce sample concentration to a few micromolars. Nevertheless, the absence of a fully automated solution to measure several hundreds of samples with photoinduced hyperpolarization limits the large-scale applicability of the method. We present a setup to couple an optical fiber with a cryogenic probe using the flow-cell accessory port. This setup is compatible with commercially available autosamplers, enabling the fully automated measurement of several hundreds of samples per day.
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Registered trials
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