ArticleQuantitative imaging in medicine and surgery2025
Quantitative susceptibility mapping study of deep gray matter iron content in glioma patients.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
7 authors.
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Abstract
Background: Iron is associated with the pathophysiology of gliomas. The measurement of brain iron levels plays a vital role in defining the pathophysiologic changes caused by gliomas. This study aimed to analyze the effect of gliomas with different histopathology and molecular characteristics on deep gray matter (DGM) iron content and the relationship between DGM iron content and cognition in glioma patients (PT). Methods: In this retrospective study, we included 81 PT, categorized according to different histopathology and molecular characteristics, and 30 age- and gender-matched healthy controls (HC). Brain quantitative susceptibility mapping (QSM) maps were computed from three-dimensional (3D) multi-echo gradient-echo data using Laplacian-based phase unwrapping, a variational sharpening (V-SHARP) background field correction and the streaking artifacts reduction (STAR)-QSM method. ITK-SNAP was used to measure the susceptibility values reflecting the iron content in the regions of interest. Differences in DGM magnetic susceptibility between groups were compared. Pearson's correlation analysis assessed the relationship between DGM magnetic susceptibility and Montreal Cognitive Assessment (MoCA). Results: Compared to HC, PT showed higher DGM magnetic susceptibility. QSM analysis exhibited higher DGM magnetic susceptibility in high-grade gliomas (HGG) than low-grade gliomas (LGG). Isocitrate dehydrogenase (IDH) wild-type gliomas showed higher magnetic susceptibility than IDH mutant-type in the putamen [IDH mutant-type: interquartile range (IQR), 0.052, 0.019 ppm Conclusions: The DGM iron content, as measured by QSM, was higher in PT than in HC and correlated with tumor grade. Cognitive decline is associated with increased DGM iron content in PT. The DGM iron content could be a potential biomarker in glioma differentiation and prognosis.
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