ArticleQuantitative imaging in medicine and surgery2025
Ultrasound super-resolution imaging and shear wave elastography for the non-invasive diagnosis of non-proliferative diabetic retinopathy: a pilot study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Advanced Glycation End Products and Metabolic-Mechanical Coupling in Diabetic Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- A Novel Nomogram for Diabetic Retinopathy Prediction in Young and Middle-Aged Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
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Authors and funding
7 authors.
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Abstract
Background: Diabetic retinopathy (DR), characterized by retinal microvascular and neuroglial network damage, results from prolonged hyperglycemia. Non-proliferative DR (NPDR) frequently presents asymptomatically, complicating its early detection. This pilot study explored the use of advanced ultrasound techniques, specifically super-resolution imaging (SRI) and shear wave elastography (SWE), to non-invasively diagnose NPDR. Methods: A total of 34 patients with NPDR and 32 patients with non-DR (NDR) underwent routine, two-dimensional (2D) ultrasound to measure eye axial length and structure. Color Doppler was used to assess the posterior eye blood flow. SWE was used to measure the optic nerve stiffness. SRI was used to image the fundus microcirculation. Lastly, the parameters were compared between groups. Results: The NPDR group had greater optic nerve stiffness and lower microvascular density at the optic disc (both P<0.05). Receiver operating characteristic (ROC) analysis revealed that optic nerve elastic Young's modulus mean (Emean) >7.33 kPa and microvascular density <42.99% suggest NPDR, with microvascular density having the highest diagnostic value. The microvascular density was significantly negatively correlated with the Emean (R=-0.83; P<0.001). Conclusions: SRI and SWE were used in this pilot study to quantify vascular and optic nerve abnormalities in patients with NPDR. The detection of early microcirculatory changes and increased optic nerve stiffness has introduced innovative, non-invasive methods for the early diagnosis of NPDR.
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