ArticleQuantitative imaging in medicine and surgery2025
Quantitative assessment of biomechanical changes in oral lesions at different cancerous stages using optical coherence elastography.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Oral cancer is the sixth most common cancer worldwide. The detection, prevention, and control of oral potentially malignant disorders (OPMDs) at early stages is imperative to reduce the incidence of oral cancer. This study analyzed ultrastructural and biomechanical tissue properties during tongue cancer development in Sprague-Dawley (SD) rats using optical coherence elastography (OCE). Our investigation examined the changes associated with oral cancer pathogenesis and explored the feasibility of OCE as an early diagnostic tool for oral cancer. Methods: In this study, 4-nitroquinoline-1-oxide (4NQO) was used to induce oral carcinogenesis in SD rats. In total, 10 normal tissues, five hyperplastic lesions, eight low-grade dysplasias (LGDs), eight moderate-high-grade dysplasias (M-HGDs), seven carcinomas in situ (CISs), and seven squamous cell carcinomas (SCCs) were examined. The oral stroma changes were sequentially imaged by Results: The findings showed that OCE imaging could be used to accurately distinguish between normal, hyperplasia, atypical hyperplasia, CIS, and oral cancer. Additionally, there were significant differences in the tongue tissue biomechanics across the different lesion levels (P<0.05). Further, as the malignancy of the tongue cancer progressed in the SD rats, the level of collagen fibers gradually increased, showing a positive correlation (r=0.353, P<0.05), while the level of elastic fiber expression gradually decreased, showing a negative correlation (r=-0.776, P<0.05). The alpha-smooth muscle actin (α-SMA) scores of CIS and SCC were statistically significantly higher than those of normal, simple hyperplasia, mild atypical hyperplasia, and moderate-high atypical hyperplasia (P<0.05). Conclusions: The ability of the shaker-OCE system to obtain the structural and biomechanical characteristics of tongue tissues in a non-invasive, real-time manner was confirmed by this study. It also showed notable benefits in terms of early diagnosis and the dynamic monitoring of tongue cancer. The systematic validation of the physiopathological model revealed a strong correlation between the elastic properties of cancerous tissues and pathological evolution, which provides a theoretical basis and experimental evidence for the clinical application of OCE technology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.