ArticleQuantitative imaging in medicine and surgery2025
Segmentation of hippocampal subregion via 5-Tesla magnetic resonance imaging: a comparative study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Background: Small voxel sizes in two-dimensional (2D) hippocampal magnetic resonance imaging (MRI) facilitate subfield segmentation. However, thinner slices remain challenging despite the advancements in in-plane resolution due to the tradeoffs in image quality. A higher signal-to-noise ratio (SNR) at 5 Tesla (T) compared to 3 T could enable thinner slices; however, the effects of changes in tissue contrast and inhomogeneous B1 variation may be weaken the SNR and contrast-to-noise ratio (CNR). However, the effectiveness of current automatic segmentation tools in handling 5-T images, particularly for thinner slices, remains to be fully elucidated. This study thus aimed to assess hippocampus image quality improvement from 3 to 5 T and to evaluate the autosegmentation of the hippocampal subregion on 5 T with different slice thicknesses. Methods: This prospective study included 28 healthy participants (14 females, with a mean age of 31.8±8.96 years). T2-weighted series with 2-, 1-, and 0.7-mm slice thicknesses were acquired on 3 T and 5T. CNR, SNR, and visual scores of the molecular layer were compared. Hippocampal subregions were segmented with 5-T data using FreeSurfer and HippUnfold toolboxes. Dice coefficients of stratum radiatum, lacunosum, and moleculare (SRLM) were compared between FreeSurfer and HippUnfold. Fleiss' Kappa, the Kruskal-Wallis test, and the pairwise Wilcoxon signed-rank test were used for statistical analyses, with a P value <0.05 being considered statistically significant. Results: SNR, CNR, and visual scores were higher on 5 T than on 3 T at the same slice thickness. The SNR of the 1-mm T2 images on 5 T was comparable to that of 2-mm images on 3 T, and the CNR of the 0.7-mm images on 5 T was comparable to that of the 2-mm images on 3 T. With a reduction in slice thickness, the Dice coefficients of SRLM between HippUnfold and manual segmentation increased, while those between FreeSurfer and manual segmentation decreased. Conclusions: The 5-T magnetic resonance system offers higher SNR and CNR values for hippocampal imaging as compared to 3-T imaging. A slice thickness of 0.7-1 mm is recommended for 2D T2-weighted imaging. However, in the selection of automatic segmentation tools for hippocampal subregions, caution is advised if the slice thickness is less than 2 mm.
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