ArticleJournal of oral rehabilitation2025
Redefining Clinical Trials on Regenerative Therapies to Target Responsiveness in Temporomandibular Joint Osteoarthritis Treatment.
Article in Journal of oral rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dental Pulp Stem Cell-Derived Extracellular Vesicles Attenuated Chondrocyte Apoptosis in Early Temporomandibular Joint Osteoarthritis via Regulating Hexokinase 2.Biomolecules · 2026Article
- Sleep bruxism: a novel theoretical perspective through the lens of the free energy principle (FEP).Frontiers in behavioral neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemporomandibular joint osteoarthritis (TMJ-OA) presents a significant clinical challenge, marked by limited therapeutic options and variable patient responses. While regenerative therapies show promising results, conventional clinical trial methodologies often fail to demonstrate a significant clinical difference, largely due to response variabilities, which is critical in complex conditions like TMJ-OA. As such, methodologies traditionally used in clinical trials for regenerative therapies targeting TMJ-OA may need to be restructured to better identify and accommodate the distinctive profiles of responders and non-responders.
objectiveThis paper proposes a revised clinical trial framework that focuses on differentiating responders from non-responders within treatment groups, rather than relying solely on traditional control groups.
methodsAnalysing non-responders provides valuable insights for therapeutic individualisation and optimises patient selection, as understanding predictive factors can lead to improved outcomes. We present recommendations that integrate imaging diagnostics, chronic pain characteristics, and psychosocial assessments, offering a novel approach to enhance efficacy of TMJ-OA treatment.
conclusionThis work advocates for a re-evaluation of standard clinical trial designs to support more personalised and effective strategies for the management of TMJ-OA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.