SynthesisJournal of oral rehabilitation2025
Impact of Gastroesophageal Reflux Disease on Salivary Flow Rate, pH and Buffer Capacity: A Systematic Review and Meta-Analysis.
Synthesis in Journal of oral rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Impact of gastroesophageal reflux disease severity on dental caries and erosive tooth wear: a case control study.BMC oral health · 2026Article
- Acid stress modulates metabolo-inflammatory pathways in oral epithelial cells.bioRxiv : the preprint server for biology · 2026Article
- Salivary Characteristics and Other Risk Factors Associated with the Severity of Chemical and Mechanical Tooth Wear in At-Risk Groups: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Expanding the Phenotypic Spectrum of Degcags Syndrome: Novel Craniofacial and Oral Findings.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis systematic review and meta-analysis aimed to assess the impact of gastroesophageal reflux disease (GERD) on salivary parameters, including salivary pH (SpH), stimulated salivary flow rate (SSFR), unstimulated salivary flow rate (USFR), and salivary buffer capacity (SBC).
methodsA thorough review of the literature was carried out across various databases, following rigorous inclusion and exclusion criteria. Studies that focused on patients with GERD and assessed the specified salivary parameters were included. The data was synthesised and analysed using standard meta-analytical techniques.
resultsThe meta-analysis included 21 studies. GERD patients exhibited significantly lower SpH (MD = -0.18, 95% CI: -0.34 to -0.02), SSFR (MD = -0.35, 95% CI: -0.51 to -0.18), and SBC (MD = -0.43, 95% CI: -0.67 to -0.19) compared to healthy controls. No significant reduction was observed in USFR (MD = -0.10, 95% CI: -0.25 to 0.05). Subgroup analyses indicated significant reductions in SpH, SSFR, and SBC in both Reflux Esophagitis and Non-Erosive Reflux Disease groups. Proton pump inhibitor usage was associated with further reductions in SpH (MD = -0.22, 95% CI: -0.37 to -0.06) and SBC (MD = -0.54, 95% CI: -0.80 to -0.27), but did not significantly impact USFR. Excluding studies with high and moderate risk of bias confirmed the robustness of the significant reductions.
conclusionsWhile GERD may reduce SpH, SSFR, and SBC, the evidence supporting these conclusions is uncertain due to inherent weaknesses in the existing studies. Regular monitoring of these parameters is essential for effective oral health management in patients diagnosed with GERD.
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