Trial reportObesity (Silver Spring, Md.)2025
Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial.
Trial report in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Brain functional connectivity patterns associated with adiposity in schizophrenia.Psychiatry research. Neuroimaging · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveThis study compared effects of exercise training and diet on impulsivity-related behaviors as measured by delay discounting and related neurobiology in adults with overweight or obesity. We hypothesized that exercise versus diet would be associated with reduced delay discounting propensity (k) and increased response in brain regions involved in cognitive control (medial prefrontal cortex, anterior cingulate cortex, and bilateral anterior insulae).
methodsParticipants (N = 40) were randomized to 12 weeks of exercise training or diet intervention. At baseline and postintervention, they completed a delay discounting task during functional magnetic resonance imaging (fMRI) in fasted and fed (post-meal) conditions. Linear mixed effects models assessed fasted-fed intervention effects on k and brain response in regions of interest. Exploratory analyses assessed whole-brain, satiety-state-specific, and reaction time effects.
resultsAcross groups, k and reaction time during delay discounting decreased and weight decreased from baseline to postintervention (p values ≤ 0.010). In exploratory fed-state whole-brain analyses, a group × session effect was observed in the right dorsolateral prefrontal cortex (p < 0.005), driven by exercise-associated changes. A similar group × session interaction effect was observed in the anterior cingulate cortex (p = 0.006), also driven by reductions in fed-state response.
conclusionsBoth interventions altered delay discounting behaviors. Exercise training was associated with reduced fed-state engagement of brain regions involved in self-referential processing and regulation during decision-making.
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