Evidence map›Paper›PMID 40384485›Full record

ArticleVeterinary dermatology2025

Validation of the Equine Urticaria Activity Score for the assessment of chronic recurrent urticaria in horses.

Katharina Birkmann, Nina Waldern, Simone Jucker, Katharina Balaschitsch, Yury Zablotski, Antonia Fettelschoss-Gabriel

Abstract readValidation Study
In one paragraph

Article in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katharina BirkmannEvax AG, Guntershausen, Switzerland.ORCID https://orcid.org/0000-0002-1142-2132
Nina WaldernEvax AG, Guntershausen, Switzerland.
Simone JuckerEvax AG, Guntershausen, Switzerland.
Katharina BalaschitschEvax AG, Guntershausen, Switzerland.
Yury ZablotskiClinic for Ruminants with Ambulatory and Herd Health Services, Ludwig-Maximilians University Munich, Oberschleißheim, Germany.
Antonia Fettelschoss-GabrielEvax AG, Guntershausen, Switzerland.ORCID https://orcid.org/0000-0002-6189-172X

Funding

Evax AG and the Swiss National Fond (SNF) BRIDGE to AF-G
6 · The paper itself

Abstract

backgroundRecurrent urticaria is common in horses. The pathophysiology is poorly understood and treatment options are limited. Often, only glucocorticoids are effective for controlling clinical signs, albeit with potential adverse effects. Studies investigating new treatments need a validated objective scoring system for the grading of skin lesions to assess response. HYPOTHESIS/

objectivesThe aims were to investigate inter- and intraobserver reliability of the Equine Urticaria Activity Score (EqUAS) for the grading of skin lesions in horses with recurrent urticaria, and to examine agreement between experienced and inexperienced observers. ANIMALS: Forty privately owned horses enrolled in a therapeutic clinical trial. MATERIALS AND

methodsTen standardised photographs of both sides of the body of each horse were used to create 40 individual datasets. Five masked observers graded the photographs according to the EqUAS for calculation of interobserver reliability. Intraobserver reliability was calculated from two observers each grading the photographs twice. Scores were evaluated for reliability with Pearson's correlation (r) and for agreement with the intraclass correlation coefficient (ICC).

resultsInterobserver reliability was excellent with r = 0.9036-0.9600 (p < 0.0001). Intraobserver reliability and agreement also were excellent with r = 0.98 for each observer (p < 0.0001) and ICC = 0.945. Correlation and agreement between experienced and inexperienced observers were excellent (r = 0.9615 [p < 0.0001] and ICC = 0.941). CONCLUSIONS AND CLINICAL RELEVANCE: The EqUAS showed excellent intra- and interobserver reliability for the evaluation of skin lesions of horses with chronic recurrent urticaria. It can be a useful tool in clinical studies.

Indexed as

Chronic UrticariaHorse DiseasesUrticariaAnimalsFemaleHorsesMaleObserver VariationRecurrenceReproducibility of ResultsSeverity of Illness Indexchronic recurrent urticariaEquine Urticaria Activity Score)grading systemhorsereliability

Identifiers

PMID40384485
PMCPMC12420881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.