ArticleCirculation. Cardiovascular quality and outcomes2025
Sedentary Behavior and Cardiac Events and Mortality After Hospitalization for Acute Coronary Syndrome Symptoms: A Prospective Study.
Article in Circulation. Cardiovascular quality and outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Perceptions and Perspectives of Mission-Involved Members on Lifestyle, Non-communicable Diseases, and Health Promotion in Seventh-Day Adventist Churches in Argentina.Journal of religion and health · 2026Article
- Higher visceral fat area is inversely associated with ketosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Metabolomic signatures connect and mediate sedentary time-driven mortality risk in patients with cardiovascular disease.Frontiers in sports and active living · 2026Article
- The relationship between physical activity levels and prognosis in geriatric patients diagnosed with acute coronary syndrome.Frontiers in medicine · 2026Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundPatients hospitalized with symptoms of acute coronary syndrome remain at high risk for adverse events postdischarge, highlighting a need for modifiable therapeutic targets. The role of sedentary behavior in this risk and the potential benefits of replacing sedentary time with other activities remain unclear. This study examined the association between sedentary behavior and 1-year cardiac events/mortality among patients evaluated for acute coronary syndrome and estimated risk reductions from substituting alternative activities for sedentary time.
methodsPatients presenting to the emergency department of a New York City hospital with acute coronary syndrome symptoms were enrolled from 2016 to 2020. Sedentary behavior, light-intensity physical activity, moderate-to-vigorous physical activity, and sleep were measured via a wrist-mounted accelerometer worn for 30 days postdischarge. Cardiac events and all-cause mortality were ascertained 1 year postdischarge via participant contact, electronic health records, and the Social Security Death Index. Participants were categorized into tertiles of sedentary time, with tertile 1 representing the lowest sedentary time and tertile 3 the highest. Cox proportional hazards regression models were used to evaluate associations.
resultsOf 609 participants (mean age, 62 years; 52% male, 58% Hispanic), 8.2% experienced a cardiac event or died within 1 year. Mean sedentary time was 13.6 h/d (SD, 1.8). Sedentary time was associated with increased risk of cardiac events/mortality (tertile 2: hazard ratio [HR], 0.95 [95% CI, 0.37-2.40]; tertile 3: HR, 2.58 [95% CI, 1.11-6.03];
conclusionsSedentary behavior was associated with increased risk of 1-year cardiac events/mortality among patients evaluated for acute coronary syndrome. Replacing sedentary behavior with sleep, light-intensity physical activity, or moderate-to-vigorous physical activity was associated with lower risk. These findings highlight reducing sedentary behavior as a potential strategy to improve posthospitalization outcomes.
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