Evidence map›Paper›PMID 40384327›Full record

ArticleTransfusion2025

Platelet transfusion induces transfusion-associated circulatory overload in rats with myocardial infarction.

Philippa G Phelp, Britt Hurks, Chantal A Polet, Joris J T H Roelofs, Anita M Tuip-de Boer, Rick Kapur, Alexander P J Vlaar, Charissa E van den Brom, Robert B Klanderman

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In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Philippa G PhelpLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0002-0093-3241
Britt HurksLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Chantal A PoletLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Joris J T H RoelofsDepartment of Pathology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Anita M Tuip-de BoerLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Rick KapurSanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-1608-876X
Alexander P J VlaarLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3453-7186
Charissa E van den BromLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Robert B KlandermanLaboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Funding

Landsteiner Foundation for Blood Transfusion Research 1931FNederlandse Organisatie voor Wetenschappelijk Onderzoek 09150172010047
6 · The paper itself

Abstract

backgroundTransfusion-associated circulatory overload (TACO) accounts for 35% of transfusion-related fatalities. Previous pre-clinical studies explored plasma and red blood cell transfusion in TACO, but the effect of platelets remains unexplored. Platelet transfusions have the highest rate of adverse reactions and are associated with increased mortality in TACO patients. We aimed to determine whether platelet transfusion induces circulatory overload compared to crystalloids and whether it causes a more severe phenotype than plasma in a TACO rat model of myocardial infarction (MI).

methodsA validated TACO model in anemic Wistar rats with MI was used. Animals received platelets (n = 11), plasma (n = 10), or Ringer's lactate (n = 11). Pulmonary capillary pressure was assessed via left-ventricular end-diastolic pressure (LVEDP). The primary outcome was the change in LVEDP (ΔLVEDP) following transfusion. Secondary outcomes included pulmonary wet/dry weight ratio, oxygen tension or partial pressure of oxygen (PaO

resultsΔLVEDP following platelet transfusion (10.4 ± 4.6 mmHg) was significantly greater than Ringer's lactate (0.9 ± 1.4 mmHg; p < .001), but similar to plasma (13.0 ± 7.7 mmHg; p > .5). Pulmonary wet/dry weight ratios were comparable across groups (p > .5). At termination, PaO DISCUSSION: Platelet transfusion induces circulatory overload in a TACO rat model with heart failure when compared to crystalloids, showing a trend toward reduced oxygenation compared to plasma transfusion. Further investigation is needed to determine the pathophysiological mechanisms.

Indexed as

Myocardial InfarctionPlatelet TransfusionAnimalsCrystalloid SolutionsDisease Models, AnimalMaleRatsRats, WistarRinger's LactateCrystalloid SolutionsRinger's Lactateacute lung injuryanimal modelplatelet transfusionpulmonary edematransfusion‐associated circulatory overloadtransfusion reaction

Identifiers

PMID40384327
PMCPMC12227162

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.