ArticleSmall methods2025
Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro-Inflammation.
Article in Small methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Spatially Profiling Trace Cytokine Signatures From Microscopically Derived Skin Samples to Probe Skin Disease Inflammation.Small methods · 2026Article
- Spatially Controlled Capture and Site-Resolved Analysis of Single Extracellular Vesicles.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro-Inflammation.Small methods · 2025Article
- Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult-findings from a neonatal mouse model.Frontiers in medical technology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Traumatic Brain Injury (TBI) triggers secondary molecular processes that contribute to mortality and morbidity. Neuroinflammation is a key factor affecting patient outcomes both acutely and chronically. Traditional diagnostic tools, such as computed tomography imaging and the Glasgow Coma Scale, are limited in detecting molecular changes, particularly related to neuroinflammation. Small extracellular vesicles (sEVs) are cell-specific vesicles that enable cell-to-cell communication and are involved in TBI pathology. In this study, brain-specific sEVs are isolated by targeting brain-associated markers, sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2) and excitatory amino acid transporter 2 (EAAT2), and employed surface-enhanced Raman spectroscopy to profile inflammation-associated cytokine chemokine (C-C motif) ligand 2 (CCL2) bound to single sEV, allowing for blood-based monitoring of neuroinflammation. This approach enabled the direct assessment of neuroinflammation in both human TBI samples and a controlled cortical injury in a rat model. This study found elevated brain-specific sEVs with enhanced CCL2 in TBI samples compared to non-TBI cohorts. The results suggest that the TBI diagnostic platform can detect an increased level of brain-specific sEVs carrying neuroinflammatory signals in TBI clinical samples with high specificity and sensitivity, offering potential as a precise diagnostic tool for TBI diagnosis.
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Registered trials
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