ArticleHealthcare informatics research2025
Developing an Explainable Artificial Intelligence System for the Mobile-Based Diagnosis of Febrile Diseases Using Random Forest, LIME, and GPT.
Article in Healthcare informatics research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A machine learning approach to predict treatment response in myofascial pain patients receiving masseter trigger point injections.BMC oral health · 2026Article
- Machine learning-driven decision support for antibiotic optimization in typhoid fever based on patient profiles.BMC medical informatics and decision making · 2026Article
- Predicting early infant diagnosis (EID) results for HIV exposed infants in a resource-limited setting using machine learning models: evidence from Amhara Public Health Institute data (2024/2025).BMC infectious diseases · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
objectivesThis study proposes a mobile-based explainable artificial intelligence (XAI) platform designed for diagnosing febrile illnesses.
methodsWe integrated the interpretability offered by local interpretable model-agnostic explanations (LIME) and the explainability provided by generative pre-trained transformers (GPT) to bridge the gap in understanding and trust often created by machine learning models in critical healthcare decision-making. The developed system employed random forest for disease diagnosis, LIME for interpretation of the results, and GPT-3.5 for generating explanations in easy-to-understand language.
resultsOur model demonstrated robust performance in detecting malaria, achieving precision, recall, and F1-scores of 85%, 91%, and 88%, respectively. It performed moderately well in detecting urinary tract and respiratory tract infections, with precision, recall, and F1-scores of 80%, 65%, and 72%, and 77%, 68%, and 72%, respectively, maintaining an effective balance between sensitivity and specificity. However, the model exhibited limitations in detecting typhoid fever and human immunodeficiency virus/acquired immune deficiency syndrome, achieving lower precision, recall, and F1-scores of 69%, 53%, and 60%, and 75%, 39%, and 51%, respectively. These results indicate missed true-positive cases, necessitating further model fine-tuning. LIME and GPT-3.5 were integrated to enhance transparency and provide natural language explanations, thereby aiding decision-making and improving user comprehension of the diagnoses.
conclusionsThe LIME plots revealed key symptoms influencing the diagnoses, with bitter taste in the mouth and fever showing the highest negative influence on predictions, and GPT-3.5 provided natural language explanations that increased the reliability and trustworthiness of the system, promoting improved patient outcomes and reducing the healthcare burden.
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