ArticleBrain and behavior2025
Combined Administration of Lactobacillus or Bifidobacterium Offers Enhanced Antidepressant and Anxiolytic Activity in a Dose Dependent Manner.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Review
- Unraveling the gut microbiota-brain axis: Mechanisms, pathophysiology, and therapeutic opportunities.iScience · 2026Review
- Human oral microbiota dysbiosis may be a novel non-invasive indicator of erectile dysfunction.Journal of dental sciences · 2026Article
- Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management.International journal of molecular sciences · 2026Review
- Gut-Brain Axis in Mood Disorders: A Narrative Review of Neurobiological Insights and Probiotic Interventions.Biomedicines · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGut microbiota is strongly linked to the activity of the bidirectional gut-brain axis, which influences neuropsychological processes at multiple levels. Changes in the gut microbiota have been implicated in mood disorders, and probiotics have been explored for their ability to mitigate the effects of stress on mental health. Here, we investigated the therapeutic benefits of different concentrations and combinations of Lactobacillus and Bifidobacterium in a mouse model of stress induced depression and anxiety.
methodsSixty-three male ICR mice (6-8 weeks old; 20-25g) divided into nine groups were used for this study. The test groups underwent chronic unpredictable mild stress protocols for two weeks before receiving low (10
resultsLow doses of the probiotic formulation (mono- or combined therapy) reversed weight loss but not anhedonia. In contrast, high doses of probiotic formulations (mono- or combined therapy), along with fluoxetine, were effective in reversing the weight loss and anhedonia caused by chronic unpredictable mild stress. Probiotics ameliorated stress-induced immobility as measured by both the forced swim and tail suspension tests, while also reducing anxiety-like behavior (increased peripheral activity) in the open field test. High doses of mono- or combined therapy increased curling behavior in the tail suspension test, whereas fluoxetine failed to do so.
conclusionThis study indicates the species- and dose-dependent beneficial effects of probiotics on behavioral outcomes associated with depression while also reversing weight loss. Evidence suggests that probiotics and fluoxetine may exert antidepressant activity via different mechanisms.
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