Evidence map›Paper›PMID 40384031›Full record

Trial reportEuropean heart journal. Cardiovascular Imaging2025

Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation.

Marko A Taipale, Markku O Pentikäinen, Laura A Martelius, Aino Mutka, Soili I Kytölä, Matti Kankainen, Juha I Peltonen, Simo O Syrjälä, Arttu J I Lahtiharju, Jyri J Lommi and 3 more

Registry-linked trialAbstract readClinical TrialMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04311346 (Cardiac MRI - Approaches for New Diagnostic Noninvasive Tools for the Detection of Cardiac Allograft Rejection), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04311346 unknown statusnot on this map

Cardiac MRI - Approaches for New Diagnostic Noninvasive Tools for the Detection of Cardiac Allograft Rejection

TypeobservationalSponsorHelsinki University Central HospitalRan2020 to 2024Enrolled72ConditionsRejection Heart TransplantArmsCardiac MR
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Non-invasive imaging in heart transplant recipients: state of art and future direction.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marko A TaipaleDepartment of Pediatric Cardiology, Pediatric Research Center, New Children's Hospital, University of Helsinki and Helsinki University Hospital, PO Box 281, Stenbäckinkatu 11, Helsinki FI-00029 HUS, Finland.ORCID 0009-0001-9050-1516
Markku O PentikäinenDepartment of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Laura A MarteliusDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Aino MutkaDepartment of Pathology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Soili I KytöläLaboratory of Genetics, HUS Diagnostic Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Matti KankainenLaboratory of Genetics, HUS Diagnostic Center, Helsinki and Uusimaa Hospital District, Hematology Research Unit Helsinki, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.
Juha I PeltonenDepartment of Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Simo O SyrjäläDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Arttu J I LahtiharjuDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Jyri J LommiDepartment of Cardiology, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Timo J JahnukainenDepartment of Pediatric Nephrology and Transplantation, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Karl B LemströmDepartment of Cardiothoracic Surgery, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Tiina H OjalaDepartment of Pediatric Cardiology, Pediatric Research Center, New Children's Hospital, University of Helsinki and Helsinki University Hospital, PO Box 281, Stenbäckinkatu 11, Helsinki FI-00029 HUS, Finland.

Funding

Alfred Kordelin FoundationFinnish Ministry of Social Affairs and HealthFoundation for Paediatric ResearchHelsinki University HospitalPaediatric Research CenterThe Finnish Foundation for Cardiovascular Research
6 · The paper itself

Abstract

aimsCardiac magnetic resonance (CMR) presents a promising non-invasive method for evaluating acute rejection in heart transplant recipients. As indicators of myocardial injury, T1 and T2 mapping values are crucial for comprehending rejection patterns in heart transplants. This study aims to define CMR T1 and T2 mapping values in heart transplant patients both with and without acute rejection. METHODS AND

resultsIn this blinded prospective study, we analysed CMR data from 244 scans of 58 paediatric and adult heart transplant recipients, 1-24 months post-transplant. Rejection status was defined by endomyocardial biopsy, clinical data, and donor-derived cell-free DNA (dd-cfDNA). Over the 24 months post-transplant, global T1 and T2 values decreased significantly (T1: β = -8.9/log(month), P < 0.001; T2: β = -0.5/log(month), P < 0.001) demonstrating the gradual recovery from transplant-related myocardial injury. During acute rejection, T1 values significantly increased compared to rejection-free studies in both children [estimates at 1 month post-transplant 1188 ms (95% CI: 1161-1215) vs. 1079 ms (95% CI: 1061-1097), P < 0.001] and adults [1087 ms (95% CI: 1045-1129) vs. 1016 ms (95% CI: 1005-1027), P = 0.007]. T1 and T2 values were positively associated with dd-cfDNA (P < 0.001 and P = 0.014, respectively), and T2 values with worse left ventricular global longitudinal strain (P < 0.001).

conclusionWe provide essential T1 and T2 mapping values across cardiac segments, as well as left ventricular myocardial strain, both with and without acute rejection. These findings establish a reliable foundation for non-invasive heart transplant rejection screening. CLINICAL

trial registrationClinicalTrials.gov Identifier: NCT04311346.

Indexed as

Cell-Free Nucleic AcidsGraft RejectionHeart TransplantationMagnetic Resonance Imaging, CineAdolescentAdultBiopsyChildChild, PreschoolFemaleHumansMaleMiddle AgedProspective StudiesReproducibility of ResultsSingle-Blind MethodCell-Free Nucleic AcidsCMREMBheart transplantationrejectionT1 mappingT2 mapping

Identifiers

PMID40384031
PMCPMC12311155

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.